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International Journal of Hepatology
Volume 2013, Article ID 341636, 11 pages
http://dx.doi.org/10.1155/2013/341636
Review Article

Targeting the HGF-cMET Axis in Hepatocellular Carcinoma

1Division of Hematology-Oncology, University of Illinois at Chicago, 840 South Wood Street, Suite 820-E, MC 713, Chicago, IL 60612, USA
2Hematology/Oncology Fellowship Program, Division of Hematology-Oncology, Vanderbilt Ingram Cancer Center, 777 Preston Research Building, Nashville, TN 37232-6307, USA

Received 28 November 2012; Accepted 11 March 2013

Academic Editor: Pierluigi Toniutto

Copyright © 2013 Neeta K. Venepalli and Laura Goff. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [30 citations]

The following is the list of published articles that have cited the current article.

  • Jennifer Au, and Catherine Frenette, “Development of Tivantinib as Treatment for Hepatocellular Carcinoma.,” Journal of clinical and translational hepatology, vol. 1, no. 1, pp. 75–8, 2013. View at Publisher · View at Google Scholar
  • S. Karabulut, D. Duranyıldız, F. Tas, U. Gezer, F. Akyüz, M. Serilmez, E. Ozgür, C. T. Yasasever, S. Vatansever, and N. F. Aykan, “Clinical significance of serum circulating insulin-like growth factor-1 (IGF-1) mRNA in hepatocellular carcinoma,” Tumor Biology, vol. 35, no. 3, pp. 2729–2739, 2013. View at Publisher · View at Google Scholar
  • S. Karabulut, F. Tas, F. Akyüz, A. C. Ormeci, M. Serilmez, H. O. Soydinç, S. Vatansever, and V. Yasasever, “Clinical significance of serum hepatocyte growth factor (HGF) levels in hepatocellular carcinoma,” Tumor Biology, vol. 35, no. 3, pp. 2327–2333, 2013. View at Publisher · View at Google Scholar
  • Matthias Preusser, Berthold Streubel, Anna S Berghoff, Johannes A Hainfellner, Andreas von Deimling, Georg Widhalm, Karin Dieckmann, Adelheid Wöhrer, Monika Hackl, Christoph Zielinski, and Peter Birner, “ Amplification and overexpression of CMET is a common event in brain metastases of non-small cell lung cancer ,” Histopathology, vol. 65, no. 5, pp. 684–692, 2014. View at Publisher · View at Google Scholar
  • Anja Runge, Junhao Hu, Matthias Wieland, Jan-Philip Bergeest, Carolin Mogler, Andre Neumann, Cyrill Geraud, Bernd Arnold, Karl Rohr, Dorde Komljenovic, Peter Schirmacher, Sergij Goerdt, and Hellmut G. Augustin, “An Inducible Hepatocellular Carcinoma Model for Preclinical Evaluation of Antiangiogenic Therapy in Adult Mice,” Cancer Research, vol. 74, no. 15, pp. 4157–4169, 2014. View at Publisher · View at Google Scholar
  • Peyda Korhan, Esra Erdal, Emine Kandemis, Murat Cokakli, Deniz Nart, Funda Yilmaz, Alp Can, and Nese Atabey, “Reciprocal Activating Crosstalk between c-Met and Caveolin 1 Promotes Invasive Phenotype in Hepatocellular Carcinoma,” Plos One, vol. 9, no. 8, 2014. View at Publisher · View at Google Scholar
  • Daniel Delitto, Eva Vertes-George, Steven J. Hughes, Kevin E. Behrns, and Jose G. Trevino, “c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer,” World Journal of Gastroenterology, vol. 20, no. 26, pp. 8458–8470, 2014. View at Publisher · View at Google Scholar
  • Ildiko Mesteri, Sebastian F. Schoppmann, Matthias Preusser, and Peter Birner, “Overexpression of CMET is associated with signal transducer and activator of transcription 3 activation and diminished prognosis in oesophageal adenocarcinoma but not in squamous cell carcinoma,” European Journal of Cancer, vol. 50, no. 7, pp. 1354–1360, 2014. View at Publisher · View at Google Scholar
  • Agnieszka Anna Rucki, and Lei Zheng, “Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies.,” World journal of gastroenterology, vol. 20, no. 9, pp. 2237–46, 2014. View at Publisher · View at Google Scholar
  • Franziska Mußbach, Petra Henklein, Martin Westermann, Utz Settmacher, Frank-D. Böhmer, and Roland Kaufmann, “Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells depends on ROS formation and RTK transactivation,” Journal of Cancer Research and Clinical Oncology, 2014. View at Publisher · View at Google Scholar
  • Hong Xin, Ke Wang, Gang Hu, Fubo Xie, Kedong Ouyang, Xuzhen Tang, Minjun Wang, Danyi Wen, Yizhun Zhu, and Xiaoran Qin, “Establishment and Characterization of 7 Novel Hepatocellular Carcinoma Cell Lines from Patient-Derived Tumor Xenografts,” Plos One, vol. 9, no. 1, 2014. View at Publisher · View at Google Scholar
  • Tao Chen, Shen-Jun Yuan, Jing Wang, and Wei Hu, “Mechanism of QHF-cisplatin against hepatocellular carcinoma in a mouse model,” World Journal Of Gastroenterology, vol. 21, no. 35, pp. 10126–10136, 2015. View at Publisher · View at Google Scholar
  • Li Wang, and Shougang Zhuang, “The Role Of Tyrosine Kinase Receptors In Peritoneal Fibrosis,” Peritoneal Dialysis International, vol. 35, no. 5, pp. 497–505, 2015. View at Publisher · View at Google Scholar
  • Nir Rozenblum, Evelyne Zeira, Viviana Scaiewicz, Baruch Bulvik, Svetlana Gourevitch, Hagit Yotvat, Eithan Galun, and S. Nahum Goldberg, “Oncogenesis: An “Off-Target” Effect of Radiofrequency Ablation,” Radiology, vol. 276, no. 2, pp. 426–432, 2015. View at Publisher · View at Google Scholar
  • Haiming Luo, Hao Hong, Michael R. Slater, Stephen A. Graves, Sixiang Shi, Yunan Yang, Robert J. Nickles, Frank Fan, and Weibo Cai, “PET of c-Met in Cancer with Cu-64-Labeled Hepatocyte Growth Factor,” Journal Of Nuclear Medicine, vol. 56, no. 5, pp. 758–763, 2015. View at Publisher · View at Google Scholar
  • Albin Rudisch, Matthew Richard Dewhurst, Luminita Gabriela Horga, Nina Kramer, Nathalie Harrer, Meng Dong, Heiko van der Kuip, Andreas Wernitznig, Andreas Bernthaler, Helmut Dolznig, and Wolfgang Sommergruber, “High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NF kappa B Driven Colony-Stimulating Factor 2 (CSF2/GM-C,” Plos One, vol. 10, no. 4, 2015. View at Publisher · View at Google Scholar
  • Nir Rozenblum, Evelyne Zeira, Viviana Scaiewicz, Baruch Bulvik, Svetlana Gourevitch, Hagit Yotvat, Eithan Galun, and S. Nahum Goldberg, “Oncogenesis: An “Off-Target” Effect of Radiofrequency Ablation,” Radiology, pp. 141695, 2015. View at Publisher · View at Google Scholar
  • Renumathy Dhanasekaran, Sudhakar K. Venkatesh, Michael Torbenson, and Lewis R. Roberts, “Clinical Implications of Basic Research in Hepatocellular Carcinoma,” Journal of Hepatology, 2015. View at Publisher · View at Google Scholar
  • Lisha Chen, Chunlin Li, and Yimin Zhu, “The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy.,” Oncotarget, vol. 6, no. 30, pp. 30088–101, 2015. View at Publisher · View at Google Scholar
  • Joycelyn Lee, Jack Chan, and Su Choo, “Clinical Development of c-MET Inhibition in Hepatocellular Carcinoma,” Diseases, vol. 3, no. 4, pp. 306–324, 2015. View at Publisher · View at Google Scholar
  • F. Li, and Y.-T. Zhu, “HGF-activated Colonic Fibroblasts Mediates Carcinogenesis of Colonic Epithelial Cancer Cells via PKC-cMET-ERK1/2-COX-2 Signaling,” Cellular Signalling, 2015. View at Publisher · View at Google Scholar
  • Wai-Nam Sung, Hoi-Hin Kwok, Man-Hee Rhee, Patrick Ying-Kit Yue, and Ricky Ngok-Shun Wong, “Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor,” Journal of Ginseng Research, 2016. View at Publisher · View at Google Scholar
  • Ana Belen Fajardo-Puerta, Mireia Mato Prado, Adam E Frampton, and Long R Jiao, “ Gene of the month: HGF ,” Journal of Clinical Pathology, vol. 69, no. 7, pp. 575–579, 2016. View at Publisher · View at Google Scholar
  • Rachel N. Frisch, Kevin M. Curtis, Kristina K. Aenlle, and Guy A. Howard, “Hepatocyte growth factor and alternative splice variants - expression, regulation and implications in osteogenesis and bone health and repair,” Expert Opinion on Therapeutic Targets, pp. 1–12, 2016. View at Publisher · View at Google Scholar
  • Ping Zhang, Zhen-fang Guo, Yu-ming Xu, Yu-sheng Li, and Jing-gui Song, “N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway,” Biomedicine & Pharmacotherapy, vol. 83, pp. 658–666, 2016. View at Publisher · View at Google Scholar
  • Emanuele Rinninella, Lucia Cerrito, Irene Spinelli, Marco Cintoni, Maria Cristina Mele, Maurizio Pompili, and Antonio Gasbarrini, “Chemotherapy for Hepatocellular Carcinoma: Current Evidence and Future Perspectives,” Journal of Clinical and Translational Hepatology, vol. XX, no. XX, pp. 1–14, 2017. View at Publisher · View at Google Scholar
  • Zhiwu Jiang, Xiaofeng Jiang, Suimin Chen, Yunxin Lai, Xinru Wei, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Qifa Liu, Muyun Peng, Fenglei Yu, Jianyu Weng, Xin Du, Duanqing Pei, Pentao Liu, Yao Yao, Ping Xue, and Peng Li, “Anti-GPC3-CAR T Cells Suppress the Growth of Tumor Cells in Patient-Derived Xenografts of Hepatocellular Carcinoma,” Frontiers in Immunology, vol. 7, 2017. View at Publisher · View at Google Scholar
  • Jan Best, Guido Gerken, Clemens Schotten, Jens M Theysohn, Axel Wetter, Stefan Müller, Sonia Radünz, Maren Schulze, Ali Canbay, and Alexander Dechêne, “Novel implications in the treatment of hepatocellular carcinoma.,” Annals of gastroenterology, vol. 30, no. 1, pp. 23–32, 2017. View at Publisher · View at Google Scholar
  • William P. Harris, Kit Man Wong, Supriya Saha, Imane El Dika, and Ghassan K. Abou-Alfa, “Biomarker-Driven and Molecular Targeted Therapies for Hepatobiliary Cancers,” Seminars in Oncology, 2018. View at Publisher · View at Google Scholar
  • Takahiro Teshima, Hirotaka Matsumoto, and Hidekazu Koyama, “Soluble factors from adipose tissue-derived mesenchymal stem cells promote canine hepatocellular carcinoma cell proliferation and invasion,” Plos One, vol. 13, no. 1, pp. e0191539, 2018. View at Publisher · View at Google Scholar