Review Article

MR Imaging of Hepatocellular Adenomas and Differential Diagnosis Dilemma

Figure 4

HNF-1α-mutated adenomas. (a) Axial T2w images without fat suppression. In S I and S II multiple slightly homogeneous hyperintense lesions (asterisk indicates the largest nodule biopsied). (b-c) T1w in- and out-phased images. Due to significant intralesional presence of fat tissue, the nodules show signal drop with variable degree in c. (d–h) In dynamic evaluation after Gd-EOB-DTPA administration the nodules show poor enhancement. In (h), after 5′ the nodules are more hypointense; other lesions may be detected in both hepatic lobes (arrowheads). (i-j) In hepatobiliary phases after 10′ (i) and 20′ (j), all adenomas are hypointense relative to adjacent liver parenchyma. (k) Histology confirms presence of fat-rich hepatocytes.
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