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International Journal of Hepatology
Volume 2013 (2013), Article ID 419302, 8 pages
http://dx.doi.org/10.1155/2013/419302
Review Article

The Role of Bridging Therapy in Hepatocellular Carcinoma

Department of Surgery, College of Medicine, University of Kentucky, Lexington, KY 40536-0293, USA

Received 16 March 2013; Revised 10 October 2013; Accepted 10 October 2013

Academic Editor: Daisuke Morioka

Copyright © 2013 Roberto Galuppo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver accounting for 7% of all cancers worldwide. Most cases of HCC develop within an established background of chronic liver disease. For that reason, liver resection is only possible in selected patients. Liver transplantation has become the treatment of choice in patients with HCC, end-stage liver disease, and significant portal hypertension. Shortage of organ donors has resulted in overall increase of waiting list time with increased risk of dropout due to tumor progression. Neoadjuvant therapies have emerged as an alternative to control tumor growth in patients while waiting. The aim of this study is to review the literature on the role of bridging therapy and downstaging prior to liver transplantation in patients with HCC. We are also presenting our single-center experience of 96 patients undergoing transplantation for HCC with and without bridging therapy.