Clinical Study

Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results

Table 4

Published studies on the treatment of HCC with PVTT with yttrium-90.

Study
(author/year/microspheres type/reference)
PVTT
population/total population
6-month survival (%)Disease Control rate at
months (%)
Median OS
(months)
Median PFS
(months)

Salem et al., 2004: glass [15] 537.1
(4.1–13.9)
Woodall et al., 2009: glass [18] 3.2
Kulik et al., 2008: glass [14] Branch
PVTT: 9.9 (7.1–15.7)
Main
PVTT: 4.4 (2.9–7.4)
Tsai et al., 2010: glass and resin [17]
15 evaluable
2-3 months: 58 (RECIST)7.0
Iñarrairaegui et al., 2010: resin
[13]
642 months: 66.7 and
6 months: 50 (RECIST)
10.0
(6.6–13.3)
Hilgard et al., 2010: glass
[12]
65
(95% CI 46–92%)
3 months: 90 (RECIST) 94 (EASL)10.0 (6.0–∞)8.0 (5.9–∞)
Salem et al., 2010: glass
[16]

(35 Child A and 57 Child B)
2-3 months: 50 Child A
and 32 Child B (EASL)
10.4 (7.2–16.6) Child A
5.6 (4.5–6.7) Child B
5.6 (2.3–7.6) Child A
5.9 (4.2–7.9) Child B
Sangro et al., 2011: resin
[24]

(branch + main)
3 months: 88.9% (EASL)10.2
(7.7–11.8)
Mazzaferro et al., 2012: glass
[25]

(branch + main)
3 months: 74.3 (EASL)13.0
(9.0–17.0)
7.0
(6.0–12.0)