Central Portalization Correlates with Fibrosis but Not with Risk Factors for Nonalcoholic Steatohepatitis in Steatotic Chronic Hepatitis C

Figure 1

(a) Low magnification view of steatotic HCV liver biopsy with 4 central zones marked by squares (H&E, ×50). (b) Level section of the same liver biopsy demonstrates two central zones with microvessel and sinusoidal capillarization. In this case, the score is 2/4 = 0.5. Insets: high magnification of microvessel/sinusoidal capillarization highlighted by CD34 immunostain and arrows (CD34, ×50; insets: CD34, ×200). (c) Level section of the same liver biopsy demonstrates two central zones with ductular reaction and intermediate-phenotype hepatocytes (CK7, ×50). In this case, the score is 2/4 = 0.5. Insets: high magnification of ductular reaction/intermediate-phenotype hepatocytes highlighted by CK7 immunostain and arrows (CK7, ×50; insets: CK7, ×200).