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International Journal of Hepatology
Volume 2014, Article ID 475021, 9 pages
http://dx.doi.org/10.1155/2014/475021
Research Article

The Mind and Liver Test: A New Approach to the Diagnosis of Minimal Hepatic Encephalopathy in Resource-Poor Settings

1Department of Medical Gastroenterology, Stanley Medical College and Hospital, Chennai 600001, India
2Banner Alzheimer’s Institute, E Willetta Street, Phoenix, AZ 85006, USA
3Global Health City, Perumbakkam, Chennai, Tamil Nadu 600100, India

Received 4 September 2014; Revised 11 November 2014; Accepted 12 November 2014; Published 8 December 2014

Academic Editor: Daisuke Morioka

Copyright © 2014 Saurav Das et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. S. Bajaj, M. Hafeezullah, Y. Zadvornova et al., “The effect of fatigue on driving skills in patients with hepatic encephalopathy,” The American Journal of Gastroenterology, vol. 104, no. 4, pp. 898–905, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Sharma, B. C. Sharma, V. Puri, and S. K. Sarin, “Critical flicker frequency: diagnostic tool for minimal hepatic encephalopathy,” Journal of Hepatology, vol. 47, no. 1, pp. 67–73, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Wein, B. Popp, H. Koch, G. Oehler, and P. Schauder, “Minimal hepatic encephalopathy impairs fitness to drive,” Hepatology, vol. 39, no. 3, pp. 739–745, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. A. T. Blei and J. Córdoba, “Hepatic encephalopathy,” The American Journal of Gastroenterology, vol. 96, no. 7, pp. 1968–1976, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Romero-Gómez, F. Boza, M. S. García-Valdecasas, E. García, and J. Aguilar-Reina, “Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy,” The American Journal of Gastroenterology, vol. 96, no. 9, pp. 2718–2723, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. J. S. Bajaj, M. Hafeezullah, J. Franco et al., “Inhibitory control test for the diagnosis of minimal hepatic encephalopathy,” Gastroenterology, vol. 135, no. 5, pp. 1591.e1–1600.e1, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Kircheis, W. E. Fleig, R. Görtelmeyer, S. Grafe, and D. Häussinger, “Assessment of low-grade hepatic encephalopathy: a critical analysis,” Journal of Hepatology, vol. 47, no. 5, pp. 642–650, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Weissenborn, N. Rückert, H. Hecker, and M. P. Manns, “The number connection tests A and B: interindividual variability and use for the assessment of early hepatic encephalopathy,” Journal of Hepatology, vol. 28, no. 4, pp. 646–653, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. R. K. Dhiman, V. A. Saraswat, M. Verma, and S. R. Naik, “Figure connection test: a universal test for assessment of mental state,” Journal of Gastroenterology and Hepatology, vol. 10, no. 1, pp. 14–23, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Iduru, K. Hisamuddin, and K. D. Mullen, “Minimal hepatic encephalopathy: simplifying its diagnosis,” The American Journal of Gastroenterology, vol. 102, no. 7, pp. 1537–1538, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Bajaj, “Minimal hepatic encephalopathy matters in daily life,” World Journal of Gastroenterology, vol. 14, no. 23, pp. 3609–3615, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Ferenci, A. Lockwood, K. Mullen, R. Tarter, K. Weissenborn, and A. T. Blei, “Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998,” Hepatology, vol. 35, no. 3, pp. 716–721, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Schomerus and W. Hamster, “Quality of life in cirrhotics with minimal hepatic encephalopathy,” Metabolic Brain Disease, vol. 16, no. 1-2, pp. 37–41, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Kumar, C. Shekhar, P. Kumar, and A. S. Kundu, “Kuppuswamy's socioeconomic status scale-updating for 2007,” The Indian Journal of Pediatrics, vol. 74, no. 12, pp. 1131–1132, 2007. View at Google Scholar · View at Scopus
  15. D. J. Siegel, “Perception and cognition,” in Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry, B. Kaplan and V. Kaplan, Eds., pp. 45–50, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 9th edition, 2003. View at Google Scholar
  16. G. Kircheis, N. Hilger, and D. Häussinger, “Value of critical flicker frequency and psychometric hepatic encephalopathy score in diagnosis of low-grade hepatic encephalopathy,” Gastroenterology, vol. 146, no. 4, pp. 961.e11–969.e11, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. P. M. Bossuyt, J. B. Reitsma, D. E. Bruns et al., “Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative,” Clinical Chemistry and Laboratory Medicine, vol. 41, no. 1, pp. 68–73, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Romero-Gómez, J. Córdoba, R. Jover et al., “Value of the critical flicker frequency in patients with minimal hepatic encephalopathy,” Hepatology, vol. 45, no. 4, pp. 879–885, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Córdoba, “New assessment of hepatic encephalopathy,” Journal of Hepatology, vol. 54, no. 5, pp. 1030–1040, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Mooney, T. I. Hasssanein, R. C. Hilsabeck et al., “Utility of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in patients with end-stage liver disease awaiting liver transplant,” Archives of Clinical Neuropsychology, vol. 22, no. 2, pp. 175–186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Weissenborn, J. C. Ennen, H. Schomerus, N. Rückert, and H. Hecker, “Neuropsychological characterization of hepatic encephalopathy,” Journal of Hepatology, vol. 34, no. 5, pp. 768–773, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Iduru and K. D. Mullen, “The demise of the pencil? New computer-assisted tests for minimal hepatic encephalopathy,” Gastroenterology, vol. 135, no. 5, pp. 1455–1456, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Mardini, B. K. Saxby, and C. O. Record, “Computerized psychometric testing in minimal encephalopathy and modulation by nitrogen challenge and liver transplant,” Gastroenterology, vol. 135, no. 5, pp. 1582–1590, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. S. Bajaj, K. Saeian, M. D. Verber et al., “Inhibitory control test is a simple method to diagnose minimal hepatic encephalopathy and predict development of overt hepatic encephalopathy,” The American Journal of Gastroenterology, vol. 102, no. 4, pp. 754–760, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Amodio, P. Marchetti, F. del Piccolo et al., “Study on the sternberg paradigm in cirrhotic patients without overt hepatic encephalopathy,” Metabolic Brain Disease, vol. 13, no. 2, pp. 159–172, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Sharma and B. C. Sharma, “Predictors of minimal hepatic encephalopathy in patients with cirrhosis,” Saudi Journal of Gastroenterology, vol. 16, no. 3, pp. 181–187, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Das, R. K. Dhiman, V. A. Saraswat, M. Verma, and S. R. Naik, “Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis,” Journal of Gastroenterology and Hepatology (Australia), vol. 16, no. 5, pp. 531–535, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. R. K. Dhiman, V. A. Saraswat, B. K. Sharma et al., “Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver,” Journal of Gastroenterology and Hepatology, vol. 25, no. 6, pp. 1029–1041, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. S. Bajaj, A. Etemadian, M. Hafeezullah, and K. Saeian, “Testing for minimal hepatic encephalopathy in the United States: an AASLD survey,” Hepatology, vol. 45, no. 3, pp. 833–834, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Vergara-Gómez, M. Flavià-Olivella, M. Gil-Prades, B. Dalmau-Obrador, and J. Córdoba-Cardona, “Diagnosis and treatment of hepatic encephalopathy in Spain: results of a survey of hepatologists,” Gastroenterologia y Hepatologia, vol. 29, no. 1, pp. 1–6, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Varghese, M. A. Thiravia, B. Natarajan, and J. Venkataraman, “Critical flicker test: yet another tool for minimal hepatic encephalopathy,” European Journal of Gastroenterology and Hepatology, vol. 19, no. 11, p. 1031, 2007. View at Publisher · View at Google Scholar · View at Scopus