Review Article

What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?

Table 2

Occurrence of biliary epithelial lesions related to cholangiocarcinoma.

Peripheral ICCPerihilar CCHCCcHC-CC

Biliary fibroadenoma0 (0%)0 (0%)0 (0%)0 (0%)
Bile duct adenoma0 (0%)0 (0%)1 (4%)1 (5%)
Von Meyenburg complex9 (24.3%)6 (17.6%)7 (28.0%)6 (33.3%)
Bile duct adenoma-like lesion12 (32.4%)4 (11.8%)3 (12%)6 (33.3%)
Atypical small bile duct lesion4 (10.8%)0 (0%)0 (0%)1 (5.6%)
Biliary epithelial neoplasm (BilIN) 2/3
 Perihilar bile duct6 (16.2%)18 (52.9%)1 (4%)2 (11.1%)
 Peribiliary glands4 (10.8%)17 (50.0%)0 (0%)1 (5.6%)

CC: cholangiocarcinoma; ICC: intrahepatic CC; HCC: hepatocellular carcinoma; cHC-CC: combined hepatocellular cholangiocarcinoma.