E. coli Induced Experimental Model of Primary Biliary Cirrhosis: At Last

Table 1

Immunological and histological features of patients with primary biliary cirrhosis (PBC) and PBC-resembling experimental E.  coli-infected NOD.B6 Idd10/Idd18 mice.

	PBC	E.  coli-infected NOD.B6 Idd10/Idd18 mice
Immunological features
AMA	Yes	Yes
Anti-PDC-E2	Yes	Yes
Anti-OGDC-E2	Yes	Yes
Anti-BCOADC-E2	Yes	No
ANA	Yes	Not tested
Histology
Portal infiltration	Yes	Yes
Granuloma formation	Yes	Yes
Bile-duct destruction	Yes	Yes

PDC: pyruvate dehydrogenase complex; OGDC: 2-oxoglutarate dehydrogenase complex; BCOADC: branched-chain 2-oxoacid dehydrogenase complex.