Review Article
E. coli Induced Experimental Model of Primary Biliary Cirrhosis: At Last
Table 2
Amino acid similarities between E. coli and self-proteins in patients with primary biliary cirrhosis (PBC). There are three major targets of cross-reactive autoantibodies directed against an epitope located at the inner lipoyl domain (ILD) of human pyruvate dehydrogenase E2 complex (PDC-E2), a cross-reactive one at the outer lipoyl domain (OLD), and one mimic on the PDC E3-binding protein (E3BP). Amongst six PDC-E2 mimics originated from various E. coli proteins, four are targets of cross-reactive responses while three are unreactive, including the E. coli PDC-E2 mimic which is a weak target. Amino acids appear in standard single letter code. Sequence alignment has been performed using the BLAST2p protein-protein comparison programmes. + indicates conserved or semiconserved substitutions.
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