Effect of Platelet-Rich Plasma on CCl4-Induced Chronic Liver Injury in Male Rats
Figure 1
Effect of the platelet-rich plasma (PRP) on histopathological changes induced by CCl4 in rats. (a) (H&E ×100) liver section of normal rats showing normal hepatocytes with prominent nucleus, cytoplasm, and central vein; (b) (H&E ×250) liver sections of CCl4-treated (0.5 mL/kg i.p.) rats showing fatty chain, necrosis, and infiltration of inflammatory cells; (c) (H&E ×250) liver sections of the rats treated with PRP (0.5 mL/kg s.c.) showing well-brought out central vein hepatocytes with well-preserved cytoplasm and normal hepatocytes with prominent nucleus; (d) (H&E ×250) liver sections of the rats treated with CCl4 + PRP (0.5 mL/kg + 0.5 mL/kg s.c.) showing normal architecture of hepatocytes and mild infiltration of inflammatory cells. H: hepatocyte, CV: central vein, N: nucleus, F: foamy macrophage cells, FC: fatty chain, NC: necrosis, I: infiltration of inflammatory cells, and BD: ballooning degeneration.
