The Value of Serum Midkine Level in Diagnosis of Hepatocellular Carcinoma

Table 2

The diagnostic performance of the best cutoff values of AFP and MDK for discriminating HCC group from LC group.

	Cutoff value	AUC (95% CI)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
MDK	0.387	0.941 (0.890–0.992)	92.5	83.3	88	89.2	88.5	0.001
AFP	88.5	0.671 (0.546–0.796)	40	96.7	94.1	54.7	64.2	0.015

MDK: midkine; AFP: alpha-fetoprotein; AUC; area under the curve; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value.