Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease
Table 1
General, anthropometric, and biochemical parameters of the subjects.
Controls
NAFLD without diabetes
NAFLD with diabetes
value
Age (years)
37.9 ± 8.4
41.8 ± 7.3
42.9 ± 7.6
0.04
NAFLD Grades I, II, and III ()
—
15, 10, 0
16, 8, 1
0.62
Variables related to whole body fat
BMI (kg/m2)
24.2
0.0001
(21.7–26.6)
(24.8–31.2)
(25.7–30.1)
WHR
0.95 ± 0.1
1.0 ± 0.1
0.052
Fat percentage (%)
24.0 ± 6.7
26.6 ± 7.0
0.001
Fat mass (kg)
15.4 ± 5.6
0.002
Variables related to inflammation
ESR (mm/hr)
12.0
18.0
0.020
(8.5–19.0)
(12.0–28.5)
(10.5–33.5)
hsCRP (mg/L)
6.7
8.0
0.007
(1.5–12.3)
(9.6–13.0)
(4.0–12.0)
Variables related to liver function
Bilirubin (mg/dL)
0.6
0.5
0.5
0.916
(0.4–0.8)
(0.4–0.8)
(0.3–0.8)
SGOT (AST) (IU/L)
25.0
30.0
27.0
0.354
(21.5–31.0)
(22.0–44.5)
(22.0–44.5)
SGPT (ALT) (IU/L)
25.0
36.0
36.0
0.111
(18.5–36.0)
(23.0–57.0)
(23.0–51.5)
ALP (IU/L)
180.0
204.0
189.0
0.545
(158.5–213.5)
(165.0–250.0)
(154.0–229.5)
Variables related to lipid profile
TG (mg/dL)
132.0
140.0
161.0
0.228
(81.0–173.5)
(98.5–222.0)
(115.5–201.5)
TC (mg/dL)
168.0
191.0
0.005
(144.0–196.5)
(162.5–235.5)
(171.5–230.0)
LDL (mg/dL)
100.0
117.0
0.009
(82.5–126.0)
(99.0–138.0)
(102.0–148.5)
HDL (mg/dL)
44.0
45.0
46.0
0.423
(40.5–49.5)
(40.5–47.5)
(41.0–53.5)
VLDL (mg/dL)
20.0
0.003
(16.0–26.5)
(19.5–42.0)
(23.5–43.5)
Variables related to diabetic status
FBG (mg/dL)
89.0
97.0
0.0001
(86.0–95.0)
(90.5–101.0)
(109.5–164.0)
PPBG (mg/dL)
119.0
129.0
0.0001
(104.0–128.0)
(118.5–142.0)
(154.5–218.5)
Fasting insulin (µIU/mL)
10.5
15.6
11.4
0.323
(5.9–17.2)
(5.4–20.7)
(10.0–17.2)
HOMA-IR
2.0
3.8
0.0001
(1.3–4.0)
(1.3–5.1)
(2.6–5.5)
Values are expressed as median (IQR) or mean ± SD; versus control; versus NAFLD without diabetes. BMI: Body Mass Index; WHR: Waist Hip Ratio; ESR: Erythrocyte Sedimentation Rate; hsCRP: High-Sensitivity C Reactive Protein; SGOT: Serum Glutamic Oxaloacetic Transaminase; AST: Aspartate Transaminase; SGPT: Serum Glutamate Pyruvate Transaminase; ALT: Alanine Transaminase; ALP: Alkaline Phosphatase; IU: International Unit; TG: Triglycerides; TC: total cholesterol; LDL: Low Density Lipoprotein; HDL: High Density Lipoprotein; VLDL: Very Low Density Lipoprotein; FBG: fasting blood glucose; PPBG: postprandial blood glucose; HOMA-IR: Homeostatic Model Assessment for Insulin Resistance.
