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International Journal of Hepatology
Volume 2016, Article ID 9185987, 16 pages
Research Article

A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

1NuSirt Biopharma Inc., 11020 Solway School Rd, Knoxville, TN 37931, USA
2Center for Obesity Reversal, Department of Biology, Georgia State University, 33 Gilmer Street SE, Atlanta, GA 30302, USA

Received 7 June 2016; Revised 7 October 2016; Accepted 19 October 2016

Academic Editor: Heather Francis

Copyright © 2016 Antje Bruckbauer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

The following is the list of published articles that have cited the current article.

  • Henrik H. Hansen, Michael Feigh, Sanne S. Veidal, Kristoffer T. Rigbolt, Niels Vrang, and Keld Fosgerau, “Mouse models of non-alcoholic steatohepatitis in preclinical drug development,” Drug Discovery Today, 2017. View at Publisher · View at Google Scholar
  • Paul Cordero, Jiawei Li, and Jude A. Oben, “Obesity and NAFLD,” Obesity, pp. 1–16, 2017. View at Publisher · View at Google Scholar
  • Joseph Zhou, Scott Massey, Darren Story, and Lixin Li, “Metformin: An Old Drug with New Applications,” International Journal of Molecular Sciences, vol. 19, no. 10, pp. 2863, 2018. View at Publisher · View at Google Scholar
  • M. Noureddin, and R. Loomba, “Editorial: role of leucine-metformin-sildenafil combination in the treatment of nonalcoholic fatty liver disease (NAFLD),” Alimentary Pharmacology & Therapeutics, vol. 48, no. 3, pp. 378–379, 2018. View at Publisher · View at Google Scholar
  • N. Chalasani, R. Vuppalanchi, M. Rinella, M. S. Middleton, M. S. Siddiqui, A. S. Barritt, O. Kolterman, O. Flores, C. Alonso, M. Iruarrizaga-Lejarreta, R. Gil-Redondo, C. B. Sirlin, and M. B. Zemel, “Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease,” Alimentary Pharmacology & Therapeutics, 2018. View at Publisher · View at Google Scholar