Imaging the Abdominal Manifestations of Cystic Fibrosis

Table 1

Proposed classification of CFLD by North American CF Foundation (2007) adapted from Flass and Narkewicz [19].

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(1) Preclinical: No evidence of liver disease on exam, imaging, or laboratory values

(2) Liver involvement without cirrhosis/portal hypertension: at least one of

  Biochemical abnormalities

   (a) Persistent AST, ALT, and GGT >2 times upper limit of normal

   (b) Intermittent elevations of the above laboratory values

  Cholangiopathy (based on US, MRI, CT, and ERCP)

  Steatosis

  Fibrosis

  US abnormalities not consistent with cirrhosis

(3) CF related liver disease with cirrhosis/portal hypertension

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AST: aspartate transaminase, ALT: alanine transaminase, and GGT: gamma-glutamyl transferase.