HCV Integrated Care: A Randomized Trial to Increase Treatment Initiation and SVR with Direct Acting Antivirals
Table 1
Patient characteristics.
Total () (%)
Integrated Care () (%)
Usual Care () (%)
value
Demographics
Age
Mean (SD)
55.7 (8.4)
54.0 (8.7)
57.4 (7.7)
0.01
BMI
Mean (SD)
28.8 (5.5)
29.0 (5.8)
28.6 (5.3)
0.79
Gender
Male
75 (94.9)
37 (92.5)
38 (97.4)
0.62
Race/ethnicity
African American or Black
19 (24.1)
7 (17.5)
12 (30.8)
0.36
White
47 (59.5)
25 (62.5)
22 (56.4)
Native American
1 (1.3)
0 (0)
1 (2.6)
Hispanic
11 (13.9)
7 (17.5)
4 (10.3)
Asian/Pacific Islander
1 (1.3)
1 (2.5)
0 (0)
Marital status
Single
20 (25.3)
11 (27.5)
9 (23.1)
0.69
Married or widowed
25 (31.6)
11 (27.5)
14 (35.9)
Separated or divorced
33 (41.8)
18 (45.0)
15 (38.5)
Missing
1 (1.3)
0 (0)
1 (2.6)
Education
Grades 1 to 8
1 (1.3)
0 (0)
1 (2.6)
0.61
Grades 9 to 11
4 (5.1)
2 (5.0)
2 (5.1)
High school/GED
18 (22.8)
12 (30.0)
6 (15.4)
Some college
43 (54.4)
21 (52.5)
22 (56.4)
College grad
6 (7.6)
2 (5.0)
4 (10.2)
Post-grad
1 (1.3)
0 (0)
1 (2.6)
Missing
6 (7.6)
3 (7.5)
3 (7.7)
Employment
Full- and part-time
9 (11.4)
4 (10.0)
5 (12.8)
0.92
Unemployed
28 (35.4)
13 (32.5)
15 (38.5)
Disabled
29 (36.7)
15 (37.5)
14 (35.9)
Retired or volunteer
11 (13.9)
7 (17.5)
4 (10.2)
Missing
2 (2.5)
1 (2.5)
1 (2.6)
Homeless in last 5 years
Negative
38 (48.1)
18 (45.0)
20 (51.3)
0.51
Positive
33 (41.8)
19 (47.5)
14 (35.9)
Missing
8 (10.1)
3 (7.5)
5 (12.8)
Clinical characteristics
Primary genotype
Type 1
62 (78.5)
29 (72.5)
33 (84.6)
0.27
Types 2, 3, and 4
17 (21.5)
11 (27.5)
6 (15.4)
Fibrosis level
Mean (SD)
2.2 (1.8)
2.1 (1.8)
2.3 (1.9)
0.84
Prior liver biopsy
36 (45.6)
18 (45)
18 (46.2)
0.99
Biopsy after enrollment
18 (22.8)
8 (20)
10 (25.6)
0.60
Prior HCV treatment
14 (17.7)
7 (17.5)
7 (17.9)
0.96
Prior psychiatric illness
50 (63.3)
27 (67.5)
23 (59)
0.49
Prior substance abuse
37 (46.8)
19 (47.5)
18 (46.2)
0.99
Other prior comorbidity
34 (43%)
16 (40%)
18 (46.2)
0.65
Number of comorbid disorders
Mean (SD)
0.59 (0.81)
0.6 (0.9)
0.59 (0.72)
0.73
Eligibility screen measures
Depression (BDI) screen
Negative
22 (27.8)
14 (35.0)
8 (20.5)
0.21
Positive
56 (70.9)
26 (65.0)
30 (78.9)
Missing
1 (1.3)
0 (0)
1 (2.6)
Depression (BDI score)
Mean (SD)
15.5 (9.2)
15.4 (9.5)
15.7 (9.0)
0.96
PTSD risk screen
Positive
36 (53.7)
21 (56.8)
18 (52.9)
0.81
Alcohol (AUDIT-C) screen
Positive
15 (19.0)
7 (17.5)
8 (20.5)
0.78
AUDIT-C screen score
Mean (SD)
1.5 (2.9)
1.4 (2.5)
1.7 (3.2)
0.83
Active drug use screen
Positive
13 (16.5)
5 (12.5)
8 (20.5)
0.38
Active alcohol risk or drug use (past 6 months)
Positive
25 (31.6)
12 (30.0)
13 (33.3)
0.81
BDI screen positive score includes scores 10; VA Primary Care PTSD screen score 3; AUDIT-C screen positive score 4 at baseline; self-reported active drug use and/or positive urine toxicology in 6 months prior to baseline (excluding marijuana).
