Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999–2002
Table 2
Logistic regression of telomere length on elevated ALT, age 20 and older, and other indicators of suspected nonalcoholic fatty liver disease, NHANES 1999–2002.
Model 1, unadjusted
Model 2, demographic
Model 3, demographic and cell type adjusted
Model 4, demographic, cell type, and abdominal obesity
Model 5, demographic, cell type, and obesity
All races
All sexes
1.87 (1.19–2.94) (n = 7049)
1.09 (0.65–1.85) (n = 6127)
1.14 (0.67–1.94) (n = 6115)
1.13 (0.48–2.65) (n = 2829)
1.17 (0.52–2.62) (n = 3373)
Male
2.95 (1.43–6.09) (n = 3621)
1.13 (0.49–2.61) (n = 3195)
1.12 (0.50–2.52) (n = 3191)
0.98 (0.29–3.24) (n = 1607)
1.32 (0.42–4.17) (n = 1886)
Female
1.25 (0.71–2.20) (n = 3428)
0.91 (0.42–1.98) (n = 2932)
0.99 (0.44–2.22) (n = 2924)
1.087 (0.29–3.93) (n = 1222)
0.72 (0.20–2.57) (n = 1487)
Other Hispanic
All sexes
5.03 (1.05–24.13) (n = 312)
4.09 (0.54–31.18) (n = 269)
1.72 (0.15–19.44) (n = 268)
0.74 (0.08–6.94) (n = 128)
15.20 (0.27–860.28) (n = 160)
Male
17.00 (1.67–173.24) (n = 137)
0.52 (0.008–34.10) (n = 126)
0.06 (0.0005–7.80) (n = 125)
—
—
Female
1.86 (0.27–12.75) (n = 175)
22.51 (0.63–807.0) (n = 143)
37.14 (0.65–2109.41) (n = 143)
—
—
African-American
All
2.43 (0.86–6.86) (n = 1445)
1.86 (0.58–5.99) (n = 1190)
1.84 (0.64–5.18) (n = 1189)
2.09 (0.65–6.70) (n = 479)
3.23 (0.70–14.90) (n = 574)
Male
5.52 (1.38–22.10) (n = 696)
3.53 (0.79–15.73) (n = 567)
4.98 (1.03–24.13) (n = 566)
5.56 (0.16–192.8) (n = 291)
5.84 (0.29–119.55) (n = 315)
Female
1.34 (0.32–5.0) n = 749
1.46 (0.27–7.75) (n = 623)
1.28 (0.35–4.70) (n = 623)
2.25 (0.12–42.06) (n = 188)
2.33 (0.17–32.77) (n = 259)
Mexican-American
All
0.65 (0.31–1.35) (n = 1201)
0.39 (0.14–1.09) (n = 1007)
0.41 (0.15–1.16) (n = 1001)
0.37 (0.09–1.52) (n = 537)
0.15 (0.03–0.64) (n = 594)
Male
0.46 (0.19–1.11) (n = 537)
0.23 (0.05–1.04) (n = 471)
0.22 (0.04–1.03) (n = 470)
0.07 (.006–0.79) (n = 284)
0.012 (0.0006–0.24) (n = 296)
Female
1.10 (0.19–6.38) (n = 664)
1.03 (0.13–8.36) n = 536
1.59 (0.22–11.54) (n = 531)
6.00 (0.19–188.15) (n = 253)
0.48 (0.04–5.38) (n = 298)
Non-Hispanic White
All
1.93 (1.07–3.49) (n = 3894)
1.136 (0.62–2.07) (n = 3487)
1.20 (0.66–2.18) (n = 3483)
0.98 (0.37–2.55) (n = 1589)
0.99 (0.33–2.97) (n = 1936)
Male
3.01 (1.32–6.91) n = (2172)
1.22 (0.50–2.96) n = 1959
1.31 (0.54–3.16) (n = 1958)
0.98 (0.265–3.82) (n = 934)
1.38 (0.36–5.73) (n = 1146)
Female
1.29 (0.56–2.97) n = (1722)
0.82 (0.32–2.08) n = 1528
0.87 (0.35–2.16) (n = 1525)
0.44 (0.11–1.91) (n = 655)
0.37 (0.07–1.90) (n = 790)
Others/mixed race
All
0.14 (0.02–0.92) (n = 197)
0.00004 (0.000000001–0.14) (n = 174)
1.00e − 0.06 (2.59e − 11–0.04) (n = 174)
1.97e − 24 (1.97e − 14–0.18) (n = 96)
—
Male
0.01 (0.00003–3.28) n = (79)
0.00002 (1.62e − 09–0.18) n = 72
5.03e − 16 (8.76e – 45 − 2.90 + 13) (n = 72)
—
—
Female
0.26 (0.04–1.64) n = (118)
2.85e − 0.08 (1.61e − 17–50.50) (n = 102)
8.46e − 08 (4.25e − 14–0.17) (n = 102)
—
—
Model 1 does not adjust for any covariates. Model 2 adjusts for the following control variables: foreign birthplace, education (less than high school, high school diploma, and more than high school), married and age (as continuous), age squared, and poverty to income ratio. Model 3 adjusts for all the variables in model 2 in addition to cell type composition, blood cells (SI), lymphocytes (%), monocytes (%), platelets (%), basophils (%), eosinophils (%), and neutrophils (%). Model 4 includes all the variables in model 3 and additionally includes abdominal obesity as an outcome (in addition to elevated ALT). Model 5 adjusts for all the variables in model 2 in addition to adding obesity as an outcome (in addition to elevated ALT). Note. ;
