Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Figure 4

Increase of HO-1 expression augments mitochondrial integrity. mRNA expression of (a) MFN1, (b) MFN2, (c) OPA1, and (d) FIS1. (e) Representative western blots and densitometric analysis of (f) COX2, (g) COX4, and (h) ATP synthase. (i) Total body oxygen consumption (VO₂) of mice, in hepatic tissues of control lean mice, HF fed mice, HF fed mice + CoPP, and HF fed mice + CoPP + SnMP. Results are mean ± SE, n=6, p<0.05 versus lean mice, p<0.05 versus HF fed mice, and p<0.05 versus HF fed mice + CoPP.

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