International Journal of Hepatology / 2018 / Article / Tab 3

Research Article

Prevalence and Determinants of Significant Liver Fibrosis by Vibration-Controlled Transient Elastography in Thai Chronic Hepatitis B Patients

Table 3

Comparison of the baseline characteristics of patients with minimal fibrosis (F0-1) and significant fibrosis (F2-4).

VariableF0-1 (n = 153)F2-4 (n = 53)P-value

Age, mean (SD), y49.60 (12.73)51.21 (11.39)0.417
Male gender, n (%)52 (34.0)34 (64.2)<0.001
BMI, mean (SD), kg/m223.50 (3.49)25.30 (4.64)0.004
 <23, n (%)75 (49.0)19 (35.8)
 ≥23, n (%)34 (22.2)11 (20.8)
 ≥25, n (%)44 (28.8)23 (43.4)
Diabetes mellitus, n (%)8 (5.2)9 (17.0)0.007
HBeAg, n (%)0.998
 Positive26 (17.0)9 (17.0)
 Negative127 (83.0)44 (83.0)
HBV DNA level, n (%)0.395
 <2000 IU/mL68 (44.4)20 (37.7)
 ≥2000 IU/mL85 (55.6)33 (62.3)
Total bilirubin, mean (SD), mg/dL0.60 (0.25)0.75 (0.54)0.053
AST level, n (%)<0.001
 ≤1 x ULN142 (92.8)29 (54.7)
 >1 x ULN11 (7.2)24 (45.3)
ALT level, n (%)<0.001
 ≤1 x ULN130 (85.0)25 (47.2)
 >1 x ULN23 (15.0)28 (52.8)
ALP, median (range), U/L63 (29-280)73 (32-511)0.011
Albumin, mean (SD), g/dL4.40 (0.40)4.30 (0.40)0.134
INR, mean (SD)1.00 (0.10)1.10 (0.20)0.051
WBC, median (range), /mm36800 (2700-18900)8200 (3800-11100)0.036
Hemoglobin, mean (SD), g/dL13.00 (1.54)13.50 (1.63)0.044
Platelet, mean (SD), x109/L239.00 (60.50)221.00 (70.90)0.082

BMI: Body mass index; HBeAg: Hepatitis B e antigen;
AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ULN: Upper limit of normal;
ALP: Alkaline phosphatase; INR: International normalized ratio.