Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials

Table 2

Reported biochemistry markers and evidence of hepatotoxicity.

Laboratory test for screening hepatotoxicity	Number of studies	%
Individual laboratory test
AST	16	88.9
ALT	15	83.3
ALP	9	50.0
Total bilirubin	7	38.9
Reported as liver function tests	2	11.1
Combined laboratory test
AST or ALT	6	33.3
AST and ALP and total bilirubin	1	5.5
AST or ALT and ALP	3	16.7
AST or ALT and total bilirubin	1	5.5
AST or ALT and ALP and total bilirubin	5	27.8
Evidence of hepatotoxicity
No evidence, or not clinically significant	10	55.6
Evidence reported, with clinical significance	8	44.4