Table 4: Safety outcomes of NSAIDs included in this study.

DrugNumber of trials includedTotal number of patients includedNumber of eventsRange of hepatotoxic eventsRange of proportion
AST > 3 ULNALT > 3 ULNALT, AST, or both > 3 ULNALP > 2 ULNHy’s LawLiver-related discontinuationLiver-related hospitalization


Remark. Hy’s Law: ALT > 3 ULN, and bilirubin ≥ 2 ULN; calculated from the minimal event and the maximal event due to the possibility of overlapping of patients.