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International Journal of Hepatology
Volume 2018, Article ID 9462475, 11 pages
https://doi.org/10.1155/2018/9462475
Research Article

A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos

1Centre d’Infectiologie Lao-Christophe Mérieux, Vientiane, Laos
2IRD, UPS, UMR 152 PHARMADEV, Université de Toulouse, Toulouse, France
3Fondation Mérieux, Lyon, France
4Hôpitaux Universitaires Paris Seine Saint Denis, Université Paris 13, Sorbonne Paris Cité, Paris, France
5INSERM U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France
6Institut Pasteur, Organisation Nucléaire et Oncogenèse, Paris, France

Correspondence should be addressed to Phimpha Paboriboune; gro.soal-mcc@ahpmihp

Received 3 October 2017; Revised 1 February 2018; Accepted 18 February 2018; Published 1 April 2018

Academic Editor: Piero Luigi Almasio

Copyright © 2018 Phimpha Paboriboune et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Lao PDR is one of the most highly endemic countries for hepatitis B in Asia and the second country for liver cancer incidence. Therefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and take the decision on treatment. Methods. A retrospective-descriptive cohort study was conducted on 3,857 HBV-infected patients. Information about infection status (viral load, VL), liver function (aminotransferases), and treatments was recorded. Results. M/F sex ratio was 1.77 for a median age of 37. Patients under 37 displayed higher VL than older ones and men had higher VL than women. Initial VL ranged from <50 IU/mL to 2.5 1013 IU/mL. Median aminotransferase values were 45.5 U/L for ALAT and 44 U/L for ASAT, ranging from <8 to >2,000 U/L. Men had higher aminotransferase than women. Globally 20% of patients received treatment (mainly immunostimulant and reverse-transcriptase inhibitors); 11% had high levels of VL and liver enzymes, but only 2% of them were treated. Conclusion. Public health decisions should be taken urgently to rationalise vaccination and provide fair access to early diagnosis and treatment; otherwise the burden of HBV-associated diseases will be overwhelming for Laos in the near future.