Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma

Table 2

Univariate and multivariate analysis of prognostic factors for overall survival.

Characteristics	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Patient factors
Age (years)	1.028	0.110
Male sex	1.426	0.507
Hepatitis B	1.462	0.276
Child Pugh B	1.806	0.227
Laboratory data
ICG>15	1.353	0.575
Creatinine	0.999	0.816
Surgical factors
Major surgery	1.733	0.125
Operation time > 350min	2.156	0.029	1.834	0.108
EBL>500ml	5.400	0.005	5.286	0.007
Tumor factors
AFP>400	1.906	0.134
Tumor size>5cm	2.396	0.016	1.480	0.318
Multiple tumors	1.805	0.121
R1 resection	2.817	0.024	3.112	0.015
Inflammatory indices
PLR ≥155	2.000	0.033
NLR ≥ 2.7	2.175	0.032
PLR ≥155 and NLR ≥ 2.7	2.889	0.007	2.496	0.020

HR: hazard ratio, CI: confidence interval, ICG: indocyanine green, EBL: estimated blood loss, AFP: alpha-fetoprotein, NLR: neutrophil-to-lymphocyte ratio, and PLR: platelet-to-lymphocyte ratio.