Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma

Table 3

Univariate and multivariate analysis of prognostic factors of recurrence free survival.

Characteristics	Univariate		Multivariate
	HR (95% CI)	p value	HR (95% CI)	p value
Patient factors
Age (years)	1.012	0.266
Male sex	1.674	0.174
Hepatitis B	1.072	0.778
Child Pugh B	1.692	0.146
Laboratory data
Creatinine	0.998	0.461
ICG>15	1.164	0.677
Surgical factors
Major surgery	1.128	0.626
Operation time > 350min	1.474	0.132
EBL>500ml	1.788	0.040	1.781	0.043
Tumor factors
AFP >400	1.331	0.388
Size>5cm	1.498	0.100	0.909	0.735
Multiple tumors	1.293	0.374
R1 resection	2.492	0.013	2.340	0.029
Inflammatory indices
PLR ≥155	1.717	0.032
NLR ≥ 2.7	1.751	0.032
PLR ≥155 and NLR ≥ 2.7	2.115	0.003	1.917	0.011

HR: hazard ratio, CI: confidence interval, ICG: indocyanine green, EBL: estimated blood loss, AFP: alpha-fetoprotein, NLR: neutrophil-to-lymphocyte ratio, and PLR: platelet-to-lymphocyte ratio.