Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective

Figure 1

Metabolic role of SIRT1 in the liver. SIRT1 deactivates CRTC2 and SREBP1c to decrease early gluconeogenesis and lipogenesis, respectively, while other regulatory transcriptional factors (PGC-1α and FOXO1, PGC-1α and PGAM, and LXR and FXR) are activated in the maintenance of blood glucose and lipid homeostasis. CRTC2: CREB-regulated transcription coactivator 2; SREBP1c: sterol regulatory element-binding protein 1c; PGC-1α: peroxisome proliferator-activated receptor-γ coactivator 1α; FOXO1: forkhead box O 1; LXR: liver X receptor; FXR: farnesoid X receptor.