Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective

Figure 2

Effect of SIRT1 in HCC cell progression. SIRT1 deacetylates p53 and PTEN and results in the promotion of HCC cell proliferation. The later transcription factor is through the inactivation of the P13K/AKT signaling pathway. On the other hand, SIRT1 activates oncogenes (c-Myc, TERT, and YAP/TEAD) and is further involved in HCC cell progression. HCC: hepatocellular carcinoma; PI3K: phosphatidylinositol 3 kinase; AKT: protein kinase B; c-Myc: cellular homologue of avian myelocytomatosis virus oncogene; PTEN: phosphatase and tensin homologue deleted on chromosome 10; YAP: yes-associated protein; TEAD: TEA domain family member 4.