Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism

Figure 1

INH and RMP induced chronic liver injury in mice. Paraffin-embedded liver sections were stained with H&E, examined blindly, and graded for steatosis, inflammation, and fibrosis as described in Materials and Method. (a) H&E staining of control and INH and RMP treatment mice for 4, 12, and 24 weeks, respectively. Magnification: 10x. (b) Hepatic steatosis score, (c) liver triglyceride content of the control and experimental groups, (d) inflammation score in the liver in different weeks after INH-RMP treatment, and (e) fibrosis score are depicted as the of eight mice per group. White bars are for control while black bars are for INH+RMP-treated mice.

(a)

(b)

(c)

(d)

(e)