Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism

Figure 3

INH-RMP treatment and liver fibrosis in mice. Quantitative RT-PCR demonstrates enhanced expression of (a) PDGF-Rβ, (b) TIMP-1, (c) TGF-β, (e) MMP2, and (f) MMP9 in liver tissues during long-term INH-RMP treatment. ^# versus INH and RMP-treated mice for 4 weeks; ^‡ versus INH and RMP-treated mice for 4 and 12 weeks. (d) Hepatic TGF-β protein level of mice treated with INH-RMP for different time periods. Hepatic TGF-β content was quantified by ELISA. The results were expressed as the of 8 mice per group. versus the vehicle-treated control group; ^# versus INH and RMP-treated mice for 4 weeks; ^‡ versus INH and RMP-treated mice for 4 and 12 weeks. White bar indicates only vehicle-treated control mice, while black bar indicates INH-RMP-treated mice.

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