Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism

Table 2

INH and RMP cotreatment and hepatic oxidative stress.

Parameters	Groups
	Cont4	INH-RMP4	Cont12	INH-RMP12	Cont24	INH-RMP24
Cytosolic fraction ()
SOD (Sp activity/min/mg protein)
GPx (Sp activity/min/mg protein)
Catalase (Sp activity/min/mg protein)

Mice were cotreated with 50 mg INH and 100 mg RMP/kg body weight by oral gavage for 6 days a week for 4, 12, and 24 weeks, respectively, and were subsequently sacrificed. The results are expressed as the of 8 mice in each group. vs. respective control; ^# vs. INH-RMP treatment for 4 weeks; ^‡ vs. INH-RMP treatment for 4 and 12 weeks. Abbreviations: Cont₄, Cont₁₂, and Cont₂₄ are respective controls of 4, 12, and 24 weeks while INH-RMP₄, INH-RMP₁₂, and INH-RMP₂₄ are INH-RMP-treated animals for 4, 12, and 24 weeks, respectively.