The Influence of Donor and Recipient Complement C3 Polymorphisms on Liver Transplant Outcome

Table 1

Baseline characteristics of the study population classified by donor and recipient C3 genotype.

	Donors		Recipients		Donor vs. Recipients
					value	Test
Donor/recipient C3 genotype	SS donor	FF/FS donor	SS recipient	FF/FS recipient
All cases	282 (59.0%)	196 (41.0%)	316 (66.1%)	162 (33.9%)	<0.001	Chi-square
First transplant (%)	265 (59.3%)	182 (40.7%)	298 (66.6%)	149 (33.4%)	0.02	Chi-square
Repeat transplant (%)	17 (54.8%)	14 (45.2%)	18 (58.1%)	13 (41.9%)	1.0	Fisher’s exact
Rejection (% total rejectors)	76 (60.8%)	49 (39.2%)	90 (72.0%)	35 (28.0%)	0.08	Fisher’s exact
Rejection free (% by genotype)	206 (73.0%)	147 (75.0%)	226 (71.5%)	127 (78.4%)	0.14	Fisher’s exact
Donor/recipient genotype combinations	FX/FX	FX/SS	SS/FX	SS/SS	4 genotypes	Compared
All cases (% total)	64 (13.4%)	132 (27.6%)	98 (20.5%)	184 (38.5%)	—
Sex (% total)
Male	39 (12.9%)	82 (27.2%)	63 (20.9%)	118 (39.1%)
Female	25 (14.2%)	50 (28.4%)	35 (19.9%)	66 (37.5%)	0.96 (M vs. F)	Chi-square
Median recipient age (range) (yr)	54.5 (18.6-70.8)	50.5 (18.0-73.4)	50.2 (18.0-74.2)	53.6 (18.1-72.0)	0.04	Kruskal-Wallis
Rejection (% total)	16 (12.8%)	33 (26.4%)	19 (15.2%)	57 (45.6%)	0.197	Chi-square
Rejection free (% by genotype)	48 (75.0%)	99 (75.0%)	79 (80.6%)	127 (69.0%)
Donor type
DBD ()	56 (13.9%)	114 (28.3%)	80 (19.6%)	153 (38.0%)	0.62 vs. DCD	Chi-square
CIT—median (range) (min)	534 (114-1014)	564 (30-1140)	528 (270-906)	540 (215-1200)	0.67	Kruskal-Wallis
DCD ()	8 (10.7%)	18 (24.0%)	18 (24.0%)	31 (41.3%)	0.65 vs. DBD	Chi-square
CIT—median (range) (min)	450 (324-528)	432 (204-558)	420 (174-528)	390 (234-653)	0.87	Kruskal-Wallis
WIT—median (range) (min)	16 (13–29)	16 (9–29)	18 (11–28)	15 (8–24)	0.62	Kruskal-Wallis