Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants

Figure 1

The effect of host factors on CHB phase progression as analyzed using three different genetic association models. (a) Mendelian assumption model: major homozygote vs. heterozygote and major homozygote vs. minor heterozygote. (b) Dominant assumption model: major homozygote and heterozygote vs. minor homozygote. (c) Recessive assumption model: major homozygote vs. heterozygote and minor homozygote. Host factors analyzed were male gender, years, and IL-10 -592 genotype against different CHB phase progression: IT+IC progression to LR, IT+IC progression to ENH, and LR progression to ENH. Age was significantly associated with all CHB phase progression in all three genetic association models, while male gender was only significantly associated with the LR to ENH progression (; shown in bold).

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