Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants
Table 1
Characteristics of study populations.
Parameter
Overall ()
HBeAg positive
HBeAg negative
value
IT ()
IC ()
LR ()
ENH ()
Age (years)
44 (32–51)
36 (28–48)
36 (30–51)
43 (32.3–51)
49 (41–55.5)
<0.001
<40 years (%)
112 (39.0)
39 (52.7)
16 (57.1)
42 (40.0)
15 (18.5)
<0.001
≥40 years (%)
175 (61.0)
35 (47.3)
12 (42.9)
62 (60.0)
66 (81.5)
Gender
Male (%)
205 (71.4)
53 (71.6)
18 (64.3)
71 (68.3)
63 (77.8)
0.422
Female (%)
82 (28.6)
21 (28.4)
10 (35.7)
33 (31.7)
18 (22.2)
AST (U/L)
34 (24–58)
28 (22–39)
112 (81–149)
27 (20.8–33.3)
62.5 (43.3–120)
<0.001
ALT (U/L)
38 (24–69)
31 (20–46.5)
116 (85–179)
29 (19.3–42)
63 (36.5–105)
<0.001
HBV DNA (log10 IU/mL)
4.86 (2.47–6.59)
6.07 (3.68–8.03)
6.27 (5.18–6.97)
2.13 (1.25–2.68)
5.26 (4.27–6.52)
0.002
IT: immune tolerant; IC: immune clearance; LR: low replicative; ENH: e-negative hepatitis. Data are median (IQR) or (%) or / (%). values were calculated by ANOVA or Kruskal-Wallis test as appropriate.
