Research Article
Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants
Table 2
Distribution of TNF-α -308, IL-10 -592, and IL-10 -1082 genotypes and alleles in different phases of natural history of chronic hepatitis B (CHB).
| | Genotype | Overall | HBeAg-positive | HBeAg-negative | HWE | value | | IT | IC | LR | ENH |
| | TNF-α -308 SNP () | | | | | | | | | GG (%) | 173 (95.6) | 38 (95.0) | 15 (88.2) | 74 (97.4) | 46 (95.8) | 0.298 | 0.370 | | GA (%) | 5 (2.8) | 1 (2.5) | 1 (5.9) | 2 (2.6) | 1 (2.1) | | AA (%) | 3 (1.7) | 1 (2.5) | 1 (5.9) | 0 | 1 (2.1) | | G (%) | 351 (96.9) | 77 (96.3) | 31 (91.2) | 150 (98.7) | 93 (96.9) | | A (%) | 11 (3.1) | 3 (3.7) | 3 (8.8) | 2 (1.3) | 3 (3.1) | | IL-10 -592 SNP () | | | | | | | | | AA (%) | 139 (55.8) | 41 (61.1) | 14 (51.9) | 45 (51.1) | 39 (58.2) | 0.385 | 0.353 | | AC (%) | 89 (35.7) | 20 (29.9) | 8 (29.6) | 36 (40.9) | 25 (37.3) | | CC (%) | 21 (8.4) | 6 (9.0) | 5 (18.5) | 7 (8.0) | 3 (4.5) | | A (%) | 367 (73.7) | 102 (61.4) | 36 (66.7) | 126 (71.6) | 103 (76.9) | | C (%) | 131 (26.3) | 32 (38.6) | 18 (33.3) | 50 (28.4) | 31 (23.1) | | IL-10 -1082 SNP () | | | | | | | | | GG (%) | 167 (100.0) | 44 (26.3) | 22 (13.2) | 52 (31.1) | 49 (29.3) | N/A | N/A | | GA (%) | 0 | 0 | 0 | 0 | 0 | | AA (%) | 0 | 0 | 0 | 0 | 0 | | G (%) | 334 (100.0) | 88 (100.0) | 44 (100.0) | 104 (100.0) | 98 (100.0) | | A (%) | 0 | 0 | 0 | 0 | 0 |
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IT: immune tolerant; IC: immune clearance; LR: low replicative; ENH: e-negative hepatitis; HWE: Hardy-Weinberg equilibrium; : chi-square. Numbers (%) were presented for categorical data. |
