Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants

Table 4

Factors independently associated with the dynamics of chronic hepatitis B (CHB) determined using multivariate binomial logistic regression with backward elimination using Mendelian assumption.

Dependent variables	OR	95% CI	value
IT and IC to HBeAg-seroconversion (LR) ()
Male	0.537	0.243–1.179	0.121
	2.191	1.067–4.578	0.034
IL-10 -592 AC	0.973	0.423–2.196	0.948
IL-10 -592 CC	1.407	0.389–5.067	0.595
IT and IC to no HBeAg-seroconversion (ENH) ()
Male	1.273	0.500–3.320	0.614
	7.460	3.316–18.310	<0.001
IL-10 -592 AC	1.222	0.531–2.822	0.636
IL-10 -592 CC	0.753	0.134–3.679	0.730
HBeAg-seroconversion (LR) to no HBeAg-seroconversion (ENH) ()
Male	4.077	1.605–11.023	0.004
	5.252	2.010–14.858	0.001
IL-10 -592 AC	1.663	0.662–4.321	0.284
IL-10 -592 CC	0.294	0.053–1.355	0.129

IT: immune tolerant; IC: immune clearance; LR: low replicative; ENH: HBeAg-negative immune reactivation; OR: odds ratio; CI: confidence interval. , , and .