Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants
Table 4
Factors independently associated with the dynamics of chronic hepatitis B (CHB) determined using multivariate binomial logistic regression with backward elimination using Mendelian assumption.
Dependent variables
OR
95% CI
value
IT and IC to HBeAg-seroconversion (LR) ()
Male
0.537
0.243–1.179
0.121
2.191
1.067–4.578
0.034
IL-10 -592 AC
0.973
0.423–2.196
0.948
IL-10 -592 CC
1.407
0.389–5.067
0.595
IT and IC to no HBeAg-seroconversion (ENH) ()
Male
1.273
0.500–3.320
0.614
7.460
3.316–18.310
<0.001
IL-10 -592 AC
1.222
0.531–2.822
0.636
IL-10 -592 CC
0.753
0.134–3.679
0.730
HBeAg-seroconversion (LR) to no HBeAg-seroconversion (ENH) ()