Research Article
Pathology of Hepatocellular Carcinoma and Tumor-Bearing Liver Tissue in Association with hTERT Promoter Mutation
Table 1
hTERT promoter mutation in hepatocellular carcinoma (HCC): association with causative clinical disease.
| | Causative disease | | hTERT mutation absolute numbers and % | Wildtype hTERT absolute numbers and % | Comparative test | |
| 1 | Without causative disease | Cirrhosis | 15 (68.2) | 7 | | | 2 | With causative disease | Cirrhosis | 56 (78.9) | 15 | 2 vs. 1 | 0.30 | 3 | ALD | Cirrhosis | 27 (87.1) | 4 | 3 vs. 1 | 0.09 | 4 | Hepatitis B | Cirrhosis | 8 (57.1) | 6 | 4 vs. 1 | 0.50 | 5 | Hepatitis C | Cirrhosis | 4 | 13 | 5 vs. 1 | 0.57 | 6 | Hepatitis B and C | Cirrhosis | 0 | 1 | | | 7 | ALD and hepatitis B | Cirrhosis | 1 | 2 | | | 8 | ALD and hepatitis C | Cirrhosis | 0 | 2 | | | 9 | ALD in other combinations | Cirrhosis | 0 | 2 | | | 10 | Other | Cirrhosis | 0 | 1 | | | | Total | Cirrhosis | 71 | 22 | | | 11 | Without primary disease | Non-cirrhosis | 18 (47.7) | 20 | 11 vs. 1 | 0.11 | 12 | With primary disease | Non-cirrhosis | 12 (41.4) | 17 | 12 vs. 2 | <0.00 | 13 | ALD | Non-cirrhosis | 7 (40.0) | 6 | | | 14 | Hepatitis B | Non-cirrhosis | 3 (40.0) | 2 | | | 15 | Hepatitis C | Non-cirrhosis | 3 (50.0) | 3 | | | 16 | Hepatitis B and C | Non-cirrhosis | 0 | 0 | | | 17 | ALD and hepatitis B | Non-cirrhosis | 1 | 0 | | | 18 | ALD and hepatitis C | Non-cirrhosis | 1 | 0 | | | 19 | ALD and hepatitis B and C | Non-cirrhosis | 1 | 0 | | | 20 | Other | Non-cirrhosis | 1 (50.0) | 1 | | | 21 | Total | Non-cirrhosis | 30 | 37 | | |
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ALD: alcoholic liver disease. Chi-square test. Fisher’s exact test. |