International Journal of Hepatology

Regulation of the Hepatocyte Cell Cycle: Signaling Pathways and Protein Kinases


Publishing date
09 Nov 2012
Status
Published
Submission deadline
29 Jun 2012

Lead Editor

1Inserm UMR 991 “Liver, Metabolisms and Cancer”, Hôpital Pontchaillou, 35033 Rennes, France

2Division of Gastroenterology, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, USA

3Institut Cochin (INSERM U1016/CNRS UMR8104), 24 rue du Faubourg St Jacques, 75014 Paris, France


Regulation of the Hepatocyte Cell Cycle: Signaling Pathways and Protein Kinases

Description

The adult liver exhibits the remarkable ability to “regenerate” following surgical resection or toxic liver injuries. Restoration of the hepatic tissue occurs through rapid proliferation of adult mature hepatocytes. The hepatocytes expressing the liver-specific functions are quiescent cells that keep the ability to reenter the cell cycle. The fact that liver regeneration is supported by the active proliferation of differentiated hepatocytes rather than the expansion of progenitor cells is a unique situation among adult solid tissues. The entry into and progression through G1 phase of the cell cycle are orchestrated by complex networks of extracellular stimuli and intracellular signaling pathways, inducing profound modifications of the gene expression profile required for the switch from quiescence to proliferation. Several lines of evidences also indicate that cell cycle regulators such as the cyclin-dependent protein kinases (CDKs) and their functional partners, the cyclins and CDK inhibitors (CDKIs), show specific expression and/or activation patterns compared to the cell cycle in other cell types. In addition, polyploidy is another characteristic feature of mammalian adult hepatocytes that contributes to the specific regulation of the cell cycle in hepatocytes. We invite authors to submit original research as well as review articles that will contribute to further defining the cellular and molecular mechanisms underlying the cell cycle regulation of the adult hepatocytes.

We are more particularly interested in articles that explore the signaling pathways and the cell cycle protein kinases, controlling the proliferation of adult hepatocytes during liver regeneration in vivo or in in vitro cell models. Potential topics include, but are not limited to:

  • Liver microenvironment and initiation of liver regeneration (priming)
  • Intracellular signaling pathways and gene profile modifications controlling the priming and progression in early G1 phase of the cell cycle
  • Molecular mechanisms and protein kinases controlling the G1/S and G2/M transitions
  • Hepatic polyploidy status and cell cycle
  • Extra- and intracellular signaling pathways regulating the hepatocyte cell cycle arrest

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijhep/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 592354
  • - Editorial

Regulation of the Hepatocyte Cell Cycle: Signaling Pathways and Protein Kinases

Pascal Loyer | Anne Corlu | Chantal Desdouets
  • Special Issue
  • - Volume 2012
  • - Article ID 328372
  • - Review Article

The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control

Jean-Philippe Guégan | Christophe Frémin | Georges Baffet
  • Special Issue
  • - Volume 2012
  • - Article ID 282430
  • - Review Article

Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology

Géraldine Gentric | Chantal Desdouets | Séverine Celton-Morizur
  • Special Issue
  • - Volume 2012
  • - Article ID 785786
  • - Research Article

Combined Stimulation with the Tumor Necrosis Factor and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices

Francis Finot | Régis Masson | ... | Pascal Loyer
  • Special Issue
  • - Volume 2012
  • - Article ID 630670
  • - Review Article

Calcium Signalling and Liver Regeneration

Isabelle Garcin | Thierry Tordjmann
  • Special Issue
  • - Volume 2012
  • - Article ID 137676
  • - Review Article

Regulation of Signal Transduction by Glutathione Transferases

Julie Pajaud | Sandeep Kumar | ... | Caroline Aninat
  • Special Issue
  • - Volume 2012
  • - Article ID 689324
  • - Review Article

Regulation of the G1/S Transition in Hepatocytes: Involvement of the Cyclin-Dependent Kinase Cdk1 in the DNA Replication

Anne Corlu | Pascal Loyer
  • Special Issue
  • - Volume 2012
  • - Article ID 212530
  • - Research Article

Recovery of the Cell Cycle Inhibition in -Induced Cirrhosis by the Adenosine Derivative IFC-305

Victoria Chagoya de Sánchez | Lidia Martínez-Pérez | ... | Gabriela Velasco-Loyden
  • Special Issue
  • - Volume 2012
  • - Article ID 476910
  • - Review Article

EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration

Alexandra Collin de l'Hortet | Hélène Gilgenkrantz | Jacques-Emmanuel Guidotti
  • Special Issue
  • - Volume 2012
  • - Article ID 816125
  • - Review Article

A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver

Angélique Gougelet | Sabine Colnot
International Journal of Hepatology
 Journal metrics
Acceptance rate-
Submission to final decision70 days
Acceptance to publication35 days
CiteScore2.280
Impact Factor-
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