Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection?

Table 1

TargetScan* algorithm-predicted RAS putative miRNA/mRNA target sites.

RAS Component	Total Conserved miRNA Targets	Total Poorly Conserved miRNA Targets	Overall Total miRNA Targets
AGTR1 (AT1R)	0	56	56
AGTR2 (AT2R)	2	96	98
ACE	0	26	26
ACE2	1	57	58
AGT	1	31	32
REN	0	15	15
ATP6AP2 (PRR)	4	49	53
MAS1 (MasR)	0	12	12
LNPEP (AT4R)	5	42	47

*Source: TargetScan (April, 2009). The number of potential targets is dramatically dependent upon the algorithm utilized.