Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection?

Table 2

Patrocles* algorithm-predicted RAS component miRSNPs.

RAS Component	dbSNP#	Hetero	dbSNP	bp from Stop Codon	Loss of Function miRSNP	Gain of Function miRSNP
AGTR1 (AT1R)	rs5184	0.069	A>G	2	miR-668
	rs56343250	N.D.		40	mR-1237, -1248
	rs5185	0.130	T>G	70	miR-302c, -573	miR-143*, -301a
	rs12721277	0.028	G>A	82	miR-579
	rs5186	0.500	A>C	86	miR-155
	rs5187	N.D.	A>G	93	miR-562, -548n	miR-646
	rs1799870	0.055	C>T	135
	rs5188	0.109	G>A	317		miR-1197
	rs55707609	N.D.	A>T	335	miR-299-3p
	rs5189	0.500	G>T	437		miR-570
	rs12721276	0.061	C>A	461		miR-128, -27a
	rs12721275	0.055	C>T	484	miR-143*
	rs12721274	0.028	T>C	556	miR-641
	rs440881	N.D.	A>C	565	miR-30b
	rs1051649	N.D.	C>T	680	miR-1197	miR-7
	rs35533650	N.D.	A>G	704
	rs380400	0.500	A>G	798
	rs35393661	N.D.	->AT	803
AGTR2 (AT2R)	rs34589510	N.D.	->T	57
	rs5193	0.241	G>T	199
	rs5194	0.499	A>G	205		miR-1229
	rs11091046	0.496	A>C	501
	rs17231436	0.131	G>C	581	miR-384
	rs41312570	N.D.	C>T	645	miR-301a, -130a
	rs17231443	0.025	C>G	816		miR-548f, -570
	rs17237806	0.050	C>T	837
	rs12858432	N.D.	C>T	906
	rs12845035	0.030	C>G	1103	miR-361-3p
	rs17237820	0.073	A>T	1111	miR-548a-3p
	rs17231478	0.038	G>T	1185
	rs17237827	0.025	A>G	1274
	rs17231450	0.050	C>A	1318	miR-150*
	rs17231457	0.050	A>C	1536		miR-571
ACE	None
ACE2	None
AGT	rs61762526	0.007	G>T	33
	rs5042	0.008	C>T	40	miR-486-3p
	rs4753	0.021	G>C	158		miR-337-5p
	rs61751079	0.002	G>A	159		miR-639, -539
	rs5043	0.021	T>C	167
	rs61751080	0.002	T>A	168
	rs11684	N.D.	C>T	184	miR-103, -107
	rs1803103	N.D.	G>T	187	miR-483-3p
	rs15022	N.D.	G>T	188	miR-483-3p
	rs1803104	N.D.	A>G	316
	rs1803106	N.D.	A>C	338	miR-129-5p	miR-335*
	rs61751081	0.002	C>T	350
	rs5044	0.029	T>G	423		miR-1283, -606
	rs61762525	0.004	C>T	473		miR-548l, -559
	rs7079	0.312	C>A	556	miR-218-1*, -584
	rs55720804	0.035	C>-	573
	rs61751082	0.023	C>-	575
REN	rs11799601	0.500	C>A	48		miR-326, -330-5p
	r11571124	0.041	C>T	145	miR-138	miR-150*
ATP6AP2 (PRR)	rs5963816	0.296	A>T	266	miR-664
	rs6609080	0.186	A>G	358	miR-1179
	rs9062	N.D.	G>T	654	miR-508-5p	miR-410
	rs10536	0.334	A>G	761	miR-802	miR-140-3p, -497*
	rs1060063	0.340	T>C	809
MAS1 (MasR)	None
LNPEP (AT4R)	rs17087239	0.004	C>T	61		miR-992, -15b
	rs39602	0.488	C>G	217
	rs75912980	0.180	T>A	364		miR-1225-5p, -9
	rs1057808	0.014	T>C	408		miR-922, -15b
	rs3756618	0.028	A>T	501	miR-22*, -26b*	miR-223
	rs35838718	N.D.	A>-	561
	rs79818663	0.105	G>T	594
	rs77639920	N.D.	C>T	614	miR-664*
	rs62377081	N.D.	G>T	695	miR-302a*, -1264	miR-548l

*Source: www.patrocles.org/.