Review Article
Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection?
Table 2
Patrocles* algorithm-predicted RAS component miRSNPs.
| RAS Component | dbSNP# | Hetero | dbSNP | bp from Stop Codon | Loss of Function miRSNP | Gain of Function miRSNP |
| AGTR1 (AT1R) | rs5184 | 0.069 | A>G | 2 | miR-668 | | rs56343250 | N.D. | | 40 | mR-1237, -1248 | | rs5185 | 0.130 | T>G | 70 | miR-302c, -573 | miR-143*, -301a | rs12721277 | 0.028 | G>A | 82 | miR-579 | | rs5186 | 0.500 | A>C | 86 | miR-155 | | rs5187 | N.D. | A>G | 93 | miR-562, -548n | miR-646 | rs1799870 | 0.055 | C>T | 135 | | | rs5188 | 0.109 | G>A | 317 | | miR-1197 | rs55707609 | N.D. | A>T | 335 | miR-299-3p | | rs5189 | 0.500 | G>T | 437 | | miR-570 | rs12721276 | 0.061 | C>A | 461 | | miR-128, -27a | rs12721275 | 0.055 | C>T | 484 | miR-143* | | rs12721274 | 0.028 | T>C | 556 | miR-641 | | rs440881 | N.D. | A>C | 565 | miR-30b | | rs1051649 | N.D. | C>T | 680 | miR-1197 | miR-7 | rs35533650 | N.D. | A>G | 704 | | | rs380400 | 0.500 | A>G | 798 | | | | rs35393661 | N.D. | ->AT | 803 | | |
| AGTR2 (AT2R) | rs34589510 | N.D. | ->T | 57 | | | rs5193 | 0.241 | G>T | 199 | | | rs5194 | 0.499 | A>G | 205 | | miR-1229 | rs11091046 | 0.496 | A>C | 501 | | | rs17231436 | 0.131 | G>C | 581 | miR-384 | | rs41312570 | N.D. | C>T | 645 | miR-301a, -130a | | rs17231443 | 0.025 | C>G | 816 | | miR-548f, -570 | rs17237806 | 0.050 | C>T | 837 | | | rs12858432 | N.D. | C>T | 906 | | | rs12845035 | 0.030 | C>G | 1103 | miR-361-3p | | rs17237820 | 0.073 | A>T | 1111 | miR-548a-3p | | rs17231478 | 0.038 | G>T | 1185 | | | rs17237827 | 0.025 | A>G | 1274 | | | rs17231450 | 0.050 | C>A | 1318 | miR-150* | | | rs17231457 | 0.050 | A>C | 1536 | | miR-571 |
| ACE | None | | | | | |
| ACE2 | None | | | | | |
| AGT | rs61762526 | 0.007 | G>T | 33 | | | rs5042 | 0.008 | C>T | 40 | miR-486-3p | | rs4753 | 0.021 | G>C | 158 | | miR-337-5p | rs61751079 | 0.002 | G>A | 159 | | miR-639, -539 | rs5043 | 0.021 | T>C | 167 | | | rs61751080 | 0.002 | T>A | 168 | | | rs11684 | N.D. | C>T | 184 | miR-103, -107 | | rs1803103 | N.D. | G>T | 187 | miR-483-3p | | rs15022 | N.D. | G>T | 188 | miR-483-3p | | rs1803104 | N.D. | A>G | 316 | | | rs1803106 | N.D. | A>C | 338 | miR-129-5p | miR-335* | rs61751081 | 0.002 | C>T | 350 | | | rs5044 | 0.029 | T>G | 423 | | miR-1283, -606 | rs61762525 | 0.004 | C>T | 473 | | miR-548l, -559 | rs7079 | 0.312 | C>A | 556 | miR-218-1*, -584 | | | rs55720804 | 0.035 | C>- | 573 | | | | rs61751082 | 0.023 | C>- | 575 | | |
| REN | rs11799601 | 0.500 | C>A | 48 | | miR-326, -330-5p | | r11571124 | 0.041 | C>T | 145 | miR-138 | miR-150* |
| ATP6AP2 (PRR) | rs5963816 | 0.296 | A>T | 266 | miR-664 | | | rs6609080 | 0.186 | A>G | 358 | miR-1179 | | | rs9062 | N.D. | G>T | 654 | miR-508-5p | miR-410 | | rs10536 | 0.334 | A>G | 761 | miR-802 | miR-140-3p, -497* | | rs1060063 | 0.340 | T>C | 809 | | |
| MAS1 (MasR) | None | | | | | |
| LNPEP (AT4R) | rs17087239 | 0.004 | C>T | 61 | | miR-992, -15b | rs39602 | 0.488 | C>G | 217 | | | rs75912980 | 0.180 | T>A | 364 | | miR-1225-5p, -9 | rs1057808 | 0.014 | T>C | 408 | | miR-922, -15b | rs3756618 | 0.028 | A>T | 501 | miR-22*, -26b* | miR-223 | rs35838718 | N.D. | A>- | 561 | | | rs79818663 | 0.105 | G>T | 594 | | | rs77639920 | N.D. | C>T | 614 | miR-664* | | rs62377081 | N.D. | G>T | 695 | miR-302a*, -1264 | miR-548l |
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*Source: www.patrocles.org/.
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