Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection?

Table 3

Physiological ramifications of RAS miRSNPs.

RAS Component	Loss of Function miRSNP	Physiological Result	Gain of Function miRSNP	Physiological Result
AGTR1 (AT1R)	AT1R↑	Hypertension Cardiac/vascular remodeling Atherosclerosis	AT1R↓	Antihypertensive Antiremodeling Anti-atherosclerosis
ACE	ACE↑		ACE↓
AGT	AGT↑		AGT↓
REN	REN↑		REN↓
ATP6AP2 (PRR)	PRR↑		PRR↓
AGTR2 (AT2R)	AT2R↑	Antihypertensive Antiremodeling Antiatherosclerosis	AT2R↓	Hypertension Cardiac/vascular remodeling Atherosclerosis
ACE2	ACE2↑		ACE2↓
MAS1 (MasR)	MasR↑		MasR↓
LNPEP (AT4R)	AT4R↑		AT4R↓