Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel

Table 1

Summary of recent GWAS of hypertension and/or blood pressure.

	Publication date	Phenotype	Discovery sample			Discovery and replication meta-analysis
			𝑁	OR/beta	Lowest 𝑃-value	𝑁	OR/beta	𝑃-value
Levy et al. [66]	Sept-07	DBP	1233	—	3.31 × 10^−6	—	—	—
		SBP	1260	—	1.69 × 10^−6	—	—	—
*Wang et al. [67]	Jan-09	SBP	542	—	7.6 × 10^−5	7125	1.9	1.6 × 10^−7
Org et al. [68]	Mar-09	hypertension	364/596	0.49	2.34 × 10^−6	3808/4334	0.78	1.39 × 10^−6
Cho et al. [69]	May-09	SBP	8842	−1.309	9.1 × 10^−7	16703	−1.064	1.3 × 10^−7
Adeyemo et al. [70]	Jul-09	DBP	8842	−0.882	1.2 × 10^−6	16703	−0.63	3.0 × 10^−6
		SBP	1017	—	4.72 × 10^−8	—	—	—
		DBP	1017	—	.448	1997	—	.162
		hypertension	509/508	0.58	5.10 × 10^−7	875/1122	—	.009

*Observed an SNP with a lower 𝑃-value but did not report on it as situated in gene desert.
—Value not reported (or in the case of meta-analysis replication not attempted).