Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease

Figure 3

Major scavenger receptors and their effects on atherosclerosis. A schematic showing the role of major scavenger receptors in atherosclerosis. Red arrows indicate proatherogenic effects; green arrows indicate antiatherogenic or protective effects. SR-A (scavenger receptor class A) mediates uptake of OxLDL (oxidised low density lipoprotein) in macrophages; SCARA5 (scavenger receptor A5) down-regulation results in reduction of aortic LDL (low density lipoprotein) deposition; CD36 is probably a receptor of OxLDL; SR-B (scavenger receptor B) increases cholesterol efflux; CD163 exerts its protective actions through elevation of IL-10 and heme oxygenase; CD68 is a possible receptor for OxLDL; LOX-1 is a receptor for OxLDL; SREC-1 (scavenger receptors expressed by endothelial cells) is a receptor for AcLDL (acetylated low density lipoprotein); SR-PSOX (scavenger receptor that binds to phosphatidylserine and oxidized lipoprotein) binds to OxLDL (figure adapted from [1]).