Review Article

Roles of Beta2- and Beta3-Adrenoceptor Polymorphisms in Hypertension and Metabolic Syndrome

Table 3

Gln27Glu, 2-adrenoceptor polymorphisms: association with hypertension, metabolic syndrome (type2 diabetes (DM)), and obesity.

Authors [reference number]YearPopulationsSubjectsAssociations with the polymorphism

Large et al. [40]1997SwedishCaucasian women with a wide range of obesityAssociation with obesity
Echwald et al. [66]1998DanishCaucasian juvenile-onset obese menNo association with obesity
Hellström et al. [67]1999SwedishCaucasian men and womenAssociation with obesity only in women
Kortner et al. [68]1999GermanCaucasian with morbid obesityNo association with obesity
Xie et al. [44]2000USABlack and white AmericansNo associations with hypertension
The Quebec Family Study [41]2000CanadaCaucasian men and womenAssociation with obesity and hyperlipidemia
Hayakawa et al. [42]2000Japanese210 Japanese men from a populationNo association with obesity
Candy et al. [45]2000EnglandBlack African men (including 192 hypertensive and 123 normotensive men)No association with hypertension
Meirhaeghe et al. [47]2000French1195 middle-aged Caucasian in the urban populationAssociation with obesity in men
Kato et al. [48]2001Japanese842 hypertensive and 633 normotensive subjectsAssociation with BP levels (hypertension) in NT
Kawamura et al. [69]2001JapaneseJapanese-AmericansNo association with obesity or DM
Ukkola et al. [70]2002USA12 pairs of twins, CaucasiansAssociation with weight gain (obesity)
Kim et al. [51]2002KoreanPatients with type 2 DMAssociation with obesity, DM, and hyperlipidemia
Gonzalez-Sanchez et al. [71]2003Spanish666 Caucasian-based study (including men and women)Association with obesity only in men
The HERITAGE family study [49]2003CanadaSedentary black and white menAssociation with lower fat in obese white men
Pereira et al. [20]2003Brazilian1576 ethnically mixed population (including men and women)No association with systolic BP or BMI
The Olivetti heart study [55]2004Italian993 middle-aged men (regardless of BP levels or BMI)No association with obesity or hypertension
Tafel et al. [57]2004GermanyExtremely obese childrenNo association with obesity
Masuo et al. [21]2005JapaneseNonobese, normotensive menAssociation with BP elevation, but no association with IR
Trombetta et al. [59]2005BrazilianBrazilian healthy womenAssociation with hypertension (blunted forearm vasodilation response)
Kurabayashi et al. [63]2006JapanesePCOS womenAssociation with high prevalence of PCOS accompanying IR
Gjesing et al. [64]2007Dutch7808 white subjectsNo association with hypertension or obesity
Masuo et al. [65]2007Japanese219 nonobese, normotensive menNo association with IR

BP: blood pressure; BMI: body mass index; DM: diabetes mellitus; NIDDM: noninsulin-dependent diabetes mellitus; IR: insulin resistance; PCOS: polycystic ovary syndrome; NT: normotensive subjects.