|
| Authors [reference number] | Year | Populations | Subjects | Associations with the polymorphism |
|
| Clement et al. [76] | 1995 | French | 185 subjects with morbid obesity and | Increased capacity of weight gain |
| | | 94 subjects with normal weight | |
| Widen et al. [77] | 1995 | Finns | 335 subjects including 207 non-DM and 128 patients with NIDDM | Insulin resistance |
| Walston et al. [78] | 1995 | Pima Indians | 390 with NIDDM and 252 without NIDDM | Association with the early onset of DM2 |
| Fujisawa et al. [79] | 1996 | Japanese | Patients with NIDDM | Type 2 DM, weight gain (obesity) |
| Silver et al. [80] | 1996 | Nauruans | 65 obese subjects with NIDDM | No association with DM2 or IR |
| Fujisawa et al. [81] | 1997 | Japanese | Essential hypertension patients | No association with IR during hyperinsulinemia euglycemic glucose clamp |
| Sakane et al. [82] | 1997 | Japanese | 131 obese women versus 218 controls | Association with IR and obesity |
| Rissanen et al. [83] | 1997 | Finns | 110 with NIDDM, 183 with IR, and 82 controls | No association with NIDDM or IR |
| McFarlane-Anderson et al. [84] | 1998 | Jamaican | Population study | Association with hyperglycemia only in women, but not in men |
| Gracía-Rubi et al. [85] | 1998 | American | Postmenopausal women | Association with IR |
| Janssen et al. [86] | 1998 | Dutch | Postmenopausal women | Association with IR |
| Shiwaku et al. [87] | 1998 | Japanese | Moderate overweight men | No association with obesity |
| Ongphiphadhanakul et al. [88] | 1999 | Thais | 76 men and 135 women | No association with IR assessed by fasting insulin/glucose ratio |
| Pulkkinen et al. [89] | 1999 | Finns | 185 untreated non-DM and 119 untreated NIDDM | No association with IR or CHD in both non-DM and NIDDM |
| Christiansen et al. [90] | 1999 | Danish | 196 dizygotic twins | Association with lower insulin secreting capacity |
| Kawamura et al. [69] | 1999 | Japanese-American | Japanese living in USA versus living in Japan | Similar distribution between Japanese-America and Japanese-Japanese. Association with IR in subjects with impaired oral glucose tolerance test. |
| Stangl et al. [91] | 2001 | German | 1000 with CHD and 1000 controls | No association with prevalence of CHD or IR |
| Strazzullo et al. [92] (The Olivetti Prospective Heart Study) | 2001 | Italian | 979 population study | No association with IR observed in HOMA-IR |
| Ishii et al. [93] | 2001 | Japanese | 196 young normoglycemic men, 186 old normoglycemic men, and 122 old hyperglycaemic men | No association with IR or NIDDM |
| Kurokawa et al. [94] | 2001 | Japanese | meta-analysis in 6582 subjects | BMI (obesity) |
| Ochoa et al. [95] | 2004 | Spanish | 185 obese and 185 nonobese children | BMI (obesity) |
| Porto et al. [96] | 2004 | Argentina | 121 NT and 54 HT from 934 high school students | Association with central obesity, but no association with IR |
| Tsai et al. [97] | 2004 | Taiwanese | 299 pregnant women | No association with gestational IR |
| Ellsworth et al. [58] | 2005 | USA | 1179 African-Americans and white-Americans | BMI (obesity) |
| Masuo K, et al. [21] | 2005 | Japanese | Nonobese, normotensive men | BP elevation |
| Masuo et al. [62] | 2006 | Japanese | 55 obese normotensive men | Weight gain (obesity), BP elevation (hypertension) |
| Højlund et al. [98] | 2006 | Danish | 10 male twins | No association between heterozygous for Trp64Arg and IR or NIDDM |
| Tamaki et al. [99] | 2006 | Japanese | 1416 population study without HT, DM, or hyperlipidemia | No association with metabolic syndrome |
| Morcillo et al. [100] | 2008 | Spanish | 1020 population study | Join association of alleles of -75A and Arg64 with the risk of DM |
| Gjesing et al. [101] | 2008 | Danish | 7605 population study | Association with NIDDM and IR, but no association with obesity |
| Dunajska et al. [102] | 2008 | Polish | 284 postmenopausal women | No association with metabolic syndrome |
|
