Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis

Table 4

Multivariate linear regression analysis for the change in systolic and diastolic blood pressure at first and last followup (ΔSBP1, ΔDBP1, ΔSBP2, and ΔDBP2).

	ΔSBP1			ΔDBP1			ΔSBP2			ΔDBP2
	β	SEM	𝑃 value	β	SEM	𝑃 value	β	SEM	𝑃 value	β	SEM	𝑃 value
Age (years)	0.015	0.203	.941	−0.026	0.117	.824	0.070	0.191	.716	−0.200	0.122	.104
Sex (1=female, 2 = male)	2.669	3.990	.506	3.387	2.291	.144	−5.776	3.799	.132	−1.125	2.429	.644
SBP0 (mmHg)	−0.223	0.121	.069	0.011	0.069	.874	−0.335	0.119	.006	0.133	0.076	.085
DBP0 (mmHg)	0.122	0.198	.541	−0.162	0.113	.157	−0.051	0.205	.803	−0.485	0.131	<.001
FU-duration (weeks)	−0.251	0.160	.121	−0.099	0.092	.283	−0.031	0.013	.016	−0.018	0.008	.030
Na^+(mmol/L)	−0.273	0.799	.734	−0.704	0.459	.129	0.607	0.760	.427	−0.011	0.486	.982
K^+(mmol/L)	−12.162	11.925	.311	−5.051	6.846	.463	−16.925	12.363	.175	−3.339	7.905	.674
Na^+/K^+	−1.770	1.304	.179	−0.554	0.748	.461	−1.810	1.356	.185	−0.292	0.867	.737

(SBP₀: baseline systolic blood pressure; DBP₀: baseline diastolic blood pressure; FU: followup; Na⁺: serum sodium concentration; K⁺: serum potassium concentration).