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International Journal of Hypertension
Volume 2011, Article ID 478710, 7 pages
Review Article

Associations between Ambulatory Blood Pressure Parameters and Cerebral White Matter Lesions

Hypertension Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, IDIBAPS, Hospital Clinic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain

Received 6 April 2011; Accepted 31 May 2011

Academic Editor: Zafar Israili

Copyright © 2011 Cristina Sierra. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Silent cerebral white matter lesions (WMLs) are a common finding on magnetic resonance imaging of the brain in the elderly. However, in patients with hypertension, WMLs tend to occur earlier in life and appear to be more severe. There is a body of evidence that supports the idea that WMLs in asymptomatic hypertensive patients should be considered a silent early marker of brain damage. It is known that ambulatory blood pressure monitoring (ABPM) correlates more closely with hypertension-related organ damage than office blood pressure. This paper focuses on the associations between blood pressure parameters obtained by 24-hour ABMP and cerebral WMLs.