Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction

Table 1

Dynamics of blood pressure indicators on modeling of NO deficiency and its correction with L-norvaline (M ± m, n = 10).

Groups of animals	Functional tests	SAP, mm hg	DAP, mm hg	Area of vascular reaction	CED
Intact	Before test	137,7 ± 3,7	101,9 ± 4,3		1,1 ± 0,1
	AH	84,3 ± 4,5	38,7 ± 2,8	1268,0 ± 74,8
	NP	83,0 ± 3,7	42,1 ± 4,4	1375,3 ± 93,7
L-NAME 25 mg/kg	Before test	190,3 ± 6,7*	145,0 ± 3,9*		5,4 ± 0,6*
	AH	110,6 ± 5,2*	82,8 ± 6,6*	695,3 ± 87,6*
	NP	88,7 ± 4,7	50,8 ± 4,2	3322,7 ± 116,7*
L-NAME 25 mg/kg + L-norvaline 10 mg/kg	Before test	180 ± 4,7*	144,6 ± 10,2*		2,1 ± 0,2**
	AH	106,7 ± 4,9*	56,1 ± 1,8*	1360,6 ± 126,9*
	NP	129,3 ± 5,1**	64,6 ± 2,5**	2827,2 ± 429,1**

* 𝑃<.05 in comparison with intact group of animals; **𝑃<.05 in comparison with L-NAME group.