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International Journal of Hypertension
Volume 2011, Article ID 587303, 12 pages
Research Article

Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project

1Physiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, Uruguay
2Cardiology Department, Cardiovascular Centre, School of Medicine, CUiiDARTE, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, Uruguay
3Clinical Laboratory Department, School of Medicine, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, Uruguay
4Physics Institute, School of Sciences, CUiiDARTE, Republic University, Iguá 4225, 11400 Montevideo, Uruguay

Received 2 April 2011; Revised 26 August 2011; Accepted 27 August 2011

Academic Editor: Roberto Pontremoli

Copyright © 2011 Daniel Bia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people with nonphysiological and pathological conditions were excluded. Then, we excluded subjects with (a) cardiovascular (CV) symptoms, (b) CV disease, (c) diabetes mellitus or renal failure, and (d) traditional CV risk factors (other than age and gender). Subjects ( ) were submitted to non-invasive vascular studies (gold-standard techniques), to evaluate (1) common (CCA), internal, and external carotid plaque prevalence, (2) CCA intima-media thickness and diameter, (3) CCA stiffness (percentual pulsatility, compliance, distensibility, and stiffness index), (4) aortic stiffness (carotid-femoral pulse wave velocity), and (5) peripheral and central pressure wave-derived parameters. Age groups: ≤20, 21–30, 31–40, 41–50, 51–60, 61–70, and 71–80 years old. Age-related structural and functional vascular parameters profiles were obtained and analyzed considering data from other populations. The work has the strength of being the first, in Latin America, that uses an integrative approach to characterize vascular aging-related changes. Data could be used to define vascular aging and abnormal or disease-related changes.