Adrenocortical Causes of Hypertension

Table 3

	PAC	PRA	PAC/PRA
Medications
β-Adrenergic blockers	↓	↓↓	↑(FP)
Central α-2 agonists	↓	↓↓	↑(FP)
NSAIDs	↓	↓↓	↑(FP)
K^+-wasting diuretics	→↑	↑↑	↓(FN)
K^+-sparing diuretics	↑	↑↑	↓(FN)
ACE inhibitors	↓	↑↑	↓(FN)
ARBs	↓	↑↑	↓(FN)
Ca^2+ blockers (DHPs)	→↓	↑	↓(FN)
Renin inhibitors	↓	↓↑^1	↑(FP)^1
			↓ (FN)^1
Potassium status
Hypokalemia	↓	→↑	↓(FN)
Potassium loading	↑	→↓	↑(FP)
Dietary sodium
Sodium restricted	↑	↑↑	↓(FN)
Sodium loaded	↓	↓↓	↑(FP)
Advancing age	↓	↓↓	↑ (FP)
Other conditions
Renal impairment	→	↓	↑(FP)
PHA-2	→	↓	↑(FP)
Pregnancy	↑	↑↑	↓(FN)
Renovascular HTN	↑	↑↑	↓(FN)
Malignant HTN	↑	↑↑	↓ (FN)