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International Journal of Hypertension
Volume 2011, Article ID 653698, 8 pages
Research Article

The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis

1State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology, and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Second Road 197, Shanghai 200025, China
2Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Chongqing South Road 225, Shanghai 200025, China
3Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Ruijin Second Road 197, Shanghai 200025, China

Received 17 February 2011; Revised 20 March 2011; Accepted 14 April 2011

Academic Editor: Roberto Pontremoli

Copyright © 2011 Wenquan Niu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Single studies attempting to associate ANP gene T2238C (rs5065) polymorphism with hypertension have so far reported inconclusive results. We therefore aimed to evaluate this association via a meta-analysis. Data on 7 studies with a total of 4068 subjects were available and analyzed using the random-effects model with assessment of heterogeneity and publication bias. Overall comparison of 2238C with 2238T yielded a 23% reduced, albeit nonsignificant, risk for hypertension (95% CI: 0.38–1.59; P=.485), while accompanying significant heterogeneity (I2=88.3%) and publication bias (P=.051). Subgroup analysis by study design demonstrated opposite associations between population-based (OR=0.33; 95% CI: 0.13–0.80; P=.015) and hospital-based studies (OR=1.15; 95% CI: 0.79–1.68; P=.454). Further meta-regression analysis exclusively indicated the significant influence of study design (P=.042) on heterogeneity. Taken together, these findings support the notion that carriers of 2238C allele were at moderate decreased risk of developing hypertension, whereas study design was identified as a potentially significant source of between-study heterogeneity.